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新锐奖获奖人孙林华

孙林华，南京师范大学生命科学学院特岗研究员。孙林华长期从事植物染色质结构与表观遗传调控研究，在植物三维基因组学技术开发与环境响应机制解析方面取得了系列创新成果。他自主研发高分辨率Hi-C技术，首次构建拟南芥热胁迫下全基因组染色质三维动态图谱，揭示高温诱导的染色质全局去凝集与转座子异常激活的关联机制，填补了环境—植物染色质互作领域的空白；系统阐明植物特有蛋白EMF1与Cohesin复合体协同调控染色质结构域形成的分子机制，突破植物中不存在拓扑相关结构域的传统认知；创新性建立植物单核小体分辨率Micro-C-XL技术体系，首次在拟南芥、水稻和大豆中实现增强子—启动子环状互作网络的精准解析，揭示RNA聚合酶II转录延伸对染色质局部结构的调控作用。他主持国家自然科学基金青年项目、江苏省自然科学基金项目等多项科研任务，相关成果在Nature Communications、Molecular Cell、Science Advances等国际权威期刊发表，入选“2024年中国植物科学重要研究进展”，为我国植物表观遗传学前沿探索和作物遗传改良研究提供了关键技术支撑与理论依据。

Sun Linhua?, Special Research Fellow at the School of Life Sciences, Nanjing Normal University, has long been engaged in research on plant chromatin structure and epigenetic regulation, achieving a series of innovative results in the development of plant 3D genomics technologies and the elucidation of environmental response mechanisms.

He independently developed a high-resolution Hi-C technology, constructing the first whole-genome chromatin 3D dynamic map of?Arabidopsis thaliana?under heat stress, revealing the association between heat-induced global chromatin decondensation and transposable element activation, thereby filling the gap in the field of environment-plant chromatin interactions. He systematically elucidated the molecular mechanism by which the plant-specific protein EMF1 and the Cohesin complex collaboratively regulate chromatin domain formation, challenging the traditional notion that plants lack topologically associated domains.

Innovatively, he established a plant single-nucleosome-resolution Micro-C-XL technology system, achieving for the first time the precise mapping of enhancer-promoter circular interaction networks in?Arabidopsis, rice, and soybeans, while uncovering the regulatory role of RNA polymerase II transcription elongation on local chromatin structure.

He has led multiple research projects, including the National Natural Science Foundation of China (Youth Program) and the Jiangsu Natural Science Foundation. His findings have been published in prestigious international journals such as?Nature Communications,?Molecular Cell, and?Science Advances, and were selected as a "Key Research Progress in Chinese Plant Science (2024)." His work provides critical technical support and theoretical foundations for frontier exploration in plant epigenetics and crop genetic improvement in China.